The objective of this study is to assess the performance and capability of a kernel-based machine learning method for time-series signal classification. Applying various stages of dimension transformation, training, testing and cross-validation, we attempt to perform a binary classification using the time-series signals from each category. This study has been applied to two domains: Financial and Biomedical.The financial domain study involves identifying the possibility of collapse or survival of a company trading in the stock market. For assessing the fate of each company, we collect its real stock market data, which is basically a financial time-series composed of weekly closing stock prices in a common time-series interval. This study has been applied to various economic sectors such as Pharmaceuticals and Biotechnology, Automobiles, Oil & Gas, Water Supply etc. The data has been collected using Thomson’s Datastream software. In the biomedical study we are dealing with knee signals collected using the Vibration arthrometry technique. This study involves using the severity of cartilage degeneration for assessing the possibility omachinf a subject getting affected by Osteoarthritis or undergoing knee replacement surgery at a later stage. This non-invasive diagnostic method can also prove be an alternative to various invasive procedures used for detecting osteoarthritis. For this analysis we have used the vibroarthro-signals for about 38 abnormal and 51 normal knee joint case studies. In both studies we apply Fisher Kernels incorporated with Gaussian Mixture Model (GMM) for dimension transformation into feature space created as a three-dimensional plot for visualization. The transformed data is then trained and tested using support vector machines for performing binary classification. From our experiments we observe that our method fits really well for both the studies with the classification error rate between 10% to 15%.