The increasing number of accidents involving chemical spills demands development of not only feasible emergency strategies, but also a consistent framework to protect the environment and prevent accidents. This can be possible only by a sound understanding of the environmental impact of spills and their potential long-term effects. Furthermore, the impact assessment of chemical spills can not be done disregarding the spatial-temporal pattern of previous exposures reciprocally influenced by both chemical and environmental properties. In this context, the thesis proposes a general framework to quantify the cumulative effects of chemical spills at any given point of a certain area based on a “present” history of exposure coupled with chemical and environmental properties designated as relevant to predict possible pictures o f future exposure and estimate in advance potential alarming levels of pollution. To achieve this purpose, the following objectives are set up. The first objective is to develop a four-dimensional model to simulate a single-spill event based on certain assumptions about chemical and soil characteristics. The second objective is to develop an algorithm to assess the cumulative effects of chemical spills on a selected area using the model for a single-spill event while taking into account the effects of those spills of the spatial-temporal zone adjacent to the study area.